ENZYMATIC SYNTHESIS OF PURINE ARABINONUCLEOSIDES

摘要

The synthesis comprises reacting a purine base with arabinose-1-phosphate in the presence of an arabinosyl-transferring enzyme system of the phosphorylase type. Arabinose-1-phosphate is preferably generated in situ, in particular from a pyrimidine arabinoside by the action of a pyrimidine nucleoside phosphorylase. The enzymes are preferably purified from E. coli B (ATCC 11303).