BETA-CARBOLINE COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES, PHARMACEUTICAL COMPOSITION BASED THEREON

摘要

This invention provides beta-carboline compounds of formula (I) wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R, Rand Rare as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2 mediated diseases such as inflammatory diseases and cancer.