发明名称 |
METHODS OF PREPARING ACTIVATED POLYMERS HAVING ALPHA NITROGEN GROUPS |
摘要 |
Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
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申请公布号 |
KR20080082994(A) |
申请公布日期 |
2008.09.12 |
申请号 |
KR20087017359 |
申请日期 |
2008.07.16 |
申请人 |
ENZON PHARMACEUTICALS, INC. |
发明人 |
ZHAO HONG;WU DECHUN |
分类号 |
C08G65/32;A61K38/16;C08G65/333;C08G65/334 |
主分类号 |
C08G65/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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