发明名称 |
Substituted 4-amino-2,6-diaryl-tetrahydrothiopyrans and salts thereof, and use as antidepressants |
摘要 |
Compounds of the steroisomeric formulas <IMAGE> and <IMAGE> wherein R1 and R2, which may be identical to or different from each other, are each phenyl, substituted phenyl, thienyl or furyl; R3 is hydrogen or straight or branched alkyl of 1 to 3 carbon atoms; and R4 is straight or branched alkyl of 1 to 3 carbon atoms; or R3 and R4, together with each other and the nitrogen atom to which they are attached, form a piperidino, 4-amino-piperidino, 4-(lower alkylamino)-piperidino, piperazino, 4-(alkyl of 1 to 2 carbon atoms)-piperazino or morpholino radical; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.
|
申请公布号 |
US4297354(A) |
申请公布日期 |
1981.10.27 |
申请号 |
US19800216423 |
申请日期 |
1980.12.15 |
申请人 |
BOEHRINGER INGELHEIM GMBH |
发明人 |
WEBER, KARL-HEINZ;SCHNEIDER, CLAUS;WALTHER, GERHARD;POOK, KARL-HEINZ;BOEKE, KARIN;BECHTEL, WOLF D. |
分类号 |
A61K31/38;A61K31/382;A61P25/24;A61P25/26;C07D335/02;C07D409/04;C07D409/14;(IPC1-7):A61K31/38;A61K31/44 |
主分类号 |
A61K31/38 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|