Thymosin beta 3 and beta 4

摘要

Two related polypeptides, thymosin beta 3 and thymosin beta 4, have been isolated from Thymosin fraction 5. These peptides have been characterized and sequenced. Thymosin beta 3 has 50 amino acid residues while thymosin beta 4 has 43 amino acid residues corresponding identically to the amino terminal 43 amino acids of thymosin beta 3. The compounds have useful biological activity as evidenced by their ability to induce terminal deoxynucleotidyl transferase (TdT) positive cells in T-cell populations. The invention described herein was made in part in the course of work under a grant or award from the Department of Health, Education and Welfare.