| 摘要 |
Compounds useful as tracers in the radioimmunoassay of xanthine derivatives such as theophylline and pharmacologically related drugs: <IMAGE> Wherein at least one R1, R3, R7 or R8 is a radioiodinated radical and wherein, if not substituted by a radioiodinated radical, the remaining R1, R3, R7 or R8 groups are otherwise identical to the substituents at these positions in the xanthine derivative to be assayed. Ordinarily, R1 is hydrogen, acetate or methyl; R3 is methyl; R7 is hydrogen, acetate or methyl; and R8 is hydrogen. The tracers are made by linking radioiodinatable or preradioiodinated radicals to the xanthine derivative which is to be assayed. The tracers may be employed in known radioimmunoassay techniques.
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