| 摘要 |
<p>Cephem intermediates(I; A,B = H, amino substituent; R = H, thiol substituent; X = hydroxy, carboxy protecting group; Z = sulfonyl group) were prepd. by treating compd.(II) with substituted amine. Thus, benzylchloroformate 100 mg was added in the tetrahydrofurane 3 ml soln. of methylα-[4-mercapto-3-phthalimido-2-oxoazetidine-1-yl -α-(1-hydroxyethylidene) acetate 100 mg and then cooled to -65oC. Triethylamine 60 mg was added in the soln., heated to the room temp. and then evapd. The residue was purified with silica gel chromatography to give methylα-[4-benzyloxycarbonylthio-3-phthalimido-2-oxoazetidine-1-yl -α-(1-benzyloxycarbonylethylidene)acetate 160 mg.</p> |
