| 摘要 |
New isobutyramide derivs. (I; R1 = halogen; n = 2-6), which have superior anticholesteremic and hypolipemic activity were prepd. Thus, mixture of 1l hydrous dichloroethane, 74g triethylamine, 52g 3-aminopropionitryl and 172g p-chloro-phenoxyisobutylchloride was refluxed for 4 hr, washed with sodium carbonate and crystallized with di-isopropylether to give N-cyanoethyl p-chlorophenoxyisobutyramide.
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