| 摘要 |
<p>A vascular prosthesis and a process for preparing the same are disclosed, which vascular prosthesis has a composite structure of a porous tubing of polytetrafluoroethylene with polyethyleneimine in the pores of the tubing, the polyethyleneimine being water-solubilzed with the amino groups quaternized and having heparin ionically bound thereto. According to this invention, a microstructure composed of fibers and nodes which is obtained by stretching a tubing of polytetrafluoroethylene in at least one axial direction and heating the stretched tubing to at least 327.degree.C is used as one starting material. Then, the pores of the microstructure are filled, with a solution of polyethyleneimine and the polyethyleneimine is subjected to a water-insolubilization treatment and a quaternization treatment. Then, heparin is ionically bound to the polyethyleneimine to form a composite structure. Thus, the invention provides a vascular prosthesis having a high rate of patency which permits a thin neointima to form on the inner surface of the prosthesis after implantation with sufficient nutrition being provided the neointima thereby to retain a neointima without degenerative change and without occulsion of the interior cavity of the prosthesis.</p> |
