摘要 |
ImidazoÄ4,5-bÜpyridin-2-ones or -2-thiones or acid-addition salts thereof, which are useful as cardiotonic agents have the Formula I where Z is O or S, Q% is PY and Q is hydrogen or lower-alkyl or Q is PY and Q% is hydrogen, R1 and R3 each are hydrogen, lower-alkyl, lower- hydroxyalkyl, 2,3-dihydroxypropyl, lower-alkoxyalkyl or Y-NB where Y is lower-alkylene having at least two carbon atoms between its connecting linkages and NB is di-(lower- alkyl)amino or 4-morpholinyl, at least one of R1 and R3 being hydrogen, but in the event that Q is PY, R1 is only hydrogen, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. They are prepared by reacting 2-R3NH-3-R1NH- 5-Q%-6-Q-pyridine with urea or carbonyldiimidazole to produce the compound where Z is O or with an alkali metal xanthate, thiourea or thiocarbonyldiimidazole to produce the compound where Z is S. |