NEW CEPHALOSPORIN DERIVATIVES, THEIR PRODUCTION AND USE AS ANTIMICROBIAL AGENTS

摘要

Compounds of the formula I in which R1 represents hydrogen, an alkyl group, a phenylalkyl group, a carboxyalkyl group, an alkoxyalkyl group, a hydroxyalkyl group, a cyanoalkyl group or a carbamidoalkyl group, R2 represents hydrogen or an easily cleavable ester group, R3 represents the pyrazolyl radical, which is optionally substituted by an alkyl group, the phenyl group, the amino group an group, an alkoxy group, an alkylthio group, the carboxyl group, the carbamido group or a carbalkoxy group, where R5 and R6 each represent an alkyl group, and R4 represents hydrogen, the acetoxy group, carbamoyloxy or 1-methyltetrazolylthio group, where the OR1 group can be in the Z- or E-position, and their salts. The compounds especially have antimicrobial properties and can be employed as antibacterially active antibiotics.