Nonthrombogenic polymer surface

摘要

Polymer surfaces which are rendered nonthrombogenic are disclosed. Polymers, including hydrophobic polymers, which can be swollen by selected solvents, are rendered nonthrombogenic by absorbing into the surface of said polymers pendant aliphatic side chains which are attached to a linear polymer having reactive pendant groups which are negatively charged or which may be reacted with compounds having a negative charge, such as heparin. The compounds absorbed into the substrate surface have multi-point attachment to the surface.