| 摘要 |
PURPOSE:A prolonged action complex capable of releasing a physiologically active substance at long intervals, obtained by forming a core including a physiologically active substance, an interval layer not including it, and an outermost layer including it successively in this order. CONSTITUTION:A physiologically active substance (e.g., testrone) is blended with a vinyl type polymerizable monomer (e.g., hydroxyethyl acrylate) to be supercooled, a natural or synthetic high polymer substance (e.g., polymethyl methacrylate) and a substance system selected from their mixture, to give a blend which is formed into a given shape and processed by a physical operation to give a prolonged action complex. A film consisting of a substance system equal to the above-mentioned substance system is formed on the surface of the prolonged action complex, to form an interval layer having no physiologically active substance. A layer including a physiologically active substance is made on the interval layer. Formation of polylayer is carried out arbitrarily in the order. The release of the physiologically active substance is carried out periodically. |
