| 发明名称 |
PROCESS FOR PREPARATION OF 7-ALKOXY-3- CHLOROMETHYLCEPHEMS |
| 摘要 |
<p>7-Alkoxy-3-chloromethyl-3-cephems are provided by a novel process comprising reacting a 3-methylenecepham with an alkali metal salt of a lower primary alcohol in the presence of tert-butyl hypochlorite at a temperature ranging from -80.degree.C. to 0.degree.C. The 3-chloromethylcephems provided by this invention are useful intermediates for the preparation of known cephalosporin antibiotics.</p> |
| 申请公布号 |
CA1109459(A) |
申请公布日期 |
1981.09.22 |
| 申请号 |
CA19770271405 |
申请日期 |
1977.02.09 |
| 申请人 |
LILLY (ELI) AND COMPANY |
发明人 |
KOPPEL, GARY A. |
| 分类号 |
A61K;A61K31/545;A61K31/546;C07C;C07D;C07D501/00;C07D501/04;C07D501/18;C07D501/24;C07D501/28;C07D501/32;C07D501/34;C07D501/57;C07D501/60;(IPC1-7):07D501/24 |
主分类号 |
A61K |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
