发明名称 |
Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation |
摘要 |
Compounds of the formula <IMAGE> wherein R1 is 4-biphenylyl, 4-phenoxyphenyl or 4-biphenylyl or 4-phenoxyphenyl substituted in the 4'-position by F, Cl, Br or I; R2 is H, C1-4-alkyl, hydroxy-C1-4-alkyl or pyridyl; R3 and R6 are each H or alkyl of 1-4 carbon atoms, or together are-(CH2)4-; and R4 and R5 are each H or together are a C-C bond; at least one of the radicals R2, R3 and R6 being other than hydrogen, possess valuable pharmacological properties, e.g., lower lipid levels and are anti-thrombotic.
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申请公布号 |
US4289774(A) |
申请公布日期 |
1981.09.15 |
申请号 |
US19790086604 |
申请日期 |
1979.10.19 |
申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
SCHACHT, ERICH;KURMEIER, HANS-ADOLF;GANTE, JOACHIM;LISSNER, REINHARD;MELZER, GUIDO;ORTH, DIETER |
分类号 |
A61K31/50;A61P3/06;A61P3/08;A61P7/02;A61P9/10;A61P25/00;A61P25/04;A61P29/00;C07D237/04;C07D237/14;C07D237/32;C07D401/04;(IPC1-7):C07D237/04;C07D237/26 |
主分类号 |
A61K31/50 |
代理机构 |
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代理人 |
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地址 |
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