| 摘要 |
Inhibitors of angiotensin converting enzyme which have the formula: <CHEM> wherein R is hydrogen, formyl, acetyl, propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbony, tert-butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl, pyro-L-glutamyl-L-lysyl, L-lysyl, L-arginyl or pyro-L-glutamyl; A is L-phenylalanyl, D-phenylalanyl, D, L-alanyl, D-alanyl, D-I-tryptophyl, D-tryptophyl, D,L-tyrosyl, D-tyrosyl, D,L-isoleucyl, D-isoleucyl, D,L-leucyl, D-leucyl, D,L-histidyl, D-histidyl, D,L-valyl, or D-valyl, the alpha -amino group thereof being in amide linkage with R; R1 is hydrogen or methyl; R2 is L-proline L-3,4-dehydroproline, D,L-3,4-dehydroproline, L-3-hydroxyproline, L-4-hydroxyproline, L-thiazoline-4-carboxylic acid, or L-5-oxo-proline, the imino group thereof being in imide linkage with the adjacent -@-; and n is O or 1, such that when n is O, R1 is methyl are disclosed as useful anti-hypertensive agents. |
