| 摘要 |
The invention is concerned with quinoline derivatives having cardiovascular activities of the formula <CHEM> or a salt thereof, in which A-B is -CH2-CH2-, -CHOH-CH2, -CH2-CHOH-, -C(O)-CH2-, -CH2-C(O)-, -C(NOR<4>)-CH2-CH2- or -CH2-C(NOR<4>), R<1> is hydrogen, hydroxy or lower alkoxy, R<2> is hydroxy, lower alkoxy, trifluoromethyl, R<3> is ethyl or vinyl and R<4> is lower alkyl. The compounds of the formula may be in the form of their optically active enantiomers and/or their therapeutically acceptable salts. Furthermore the invention provides pharmaceutical compositions possessing cardiovascular activities, in which as active compound at least a compound of the above formula is used. Methods for the preparation of the pharmaceutical compositions and of the active compounds are also disclosed and covered by the invention. |
