发明名称 |
Derivatives of arylalkanoic acids, compositions and use |
摘要 |
There are now described some novel alpha-[1-aryl-2,2,2-trifluoroethoxy (or-ethylthio)]alkanoic acids that are useful for reducing triglycerides and cholesterol levels in the blood of animals. The percentage reduction in test rats has been observed to be from 20 to 65 for triglycerides and from 15 to 50 for cholesterol. A representative compound of the invention is alpha-(2,2,2-trifluoro-1-phenyl-1-ethoxy)butyric acid. Most of the compounds have an LD50 greater than 800 mg/kg, intraperitoneally, in male mice. A method of use, compositions, and a process for synthesis are also described.
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申请公布号 |
US4288453(A) |
申请公布日期 |
1981.09.08 |
申请号 |
US19780949571 |
申请日期 |
1978.10.10 |
申请人 |
SCIENCE UNION ET CIE |
发明人 |
VINCENT, MICHEL;DUHAULT, JACQUES;BOULLANGER, MICHELLE;REMOND, GEORGES |
分类号 |
C07C323/52;A61K31/10;A61K31/19;C07C29/70;C07C41/01;C07C41/26;C07C43/03;C07C43/23;C07C45/00;C07C45/71;C07C59/125;C07C59/66;C07C59/68;C07C69/66;C07C69/708;C07C319/14;C07D207/32;C07D207/333;C07D295/08;C07D295/096;C07D295/185;C07D307/42;C07D333/16;(IPC1-7):61K31/19;07C53/134 |
主分类号 |
C07C323/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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