发明名称 |
Fragmentation procedure for preparing 3-amino-azetidinones |
摘要 |
When 3-(2-hydroxyiminoacetylamino)-2-oxo-azetidine compounds are treated with reactive derivatives of carbonic acid half-esters in aqueous media in the presence of bases a fragmentation takes place which, in addition to 3-amino-2-oxo-azetidines, also yields nitriles which, compared with the 2-hydroxyiminoacetyl group, have one less carbon atom. The resulting products are intermediates for the preparation of nocardicin-like antibiotics. The deacylation procedure of this specification offers advantages over the multi-stage deacylation procedure known hitherto, inasmuch as higher yields of 3-amino-2-oxoazetidine compounds are obtained and the acyl group can be obtained in the form of a nitrile which is shorter by one carbon atom.
|
申请公布号 |
US4288364(A) |
申请公布日期 |
1981.09.08 |
申请号 |
US19790039239 |
申请日期 |
1979.05.15 |
申请人 |
CIBA-GEIGY CORPORATION |
发明人 |
SCHAFFNER, KARL;WEHRLI, HANSULI;MUELLER, BEAT;SCARTAZZINI, RICCARDO |
分类号 |
C07D205/085;(IPC1-7):C07D205/08;C07D403/06 |
主分类号 |
C07D205/085 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|