| 摘要 |
NEW MATERIAL:An aminoethanol derivative of formula I [A is direct bond or -O-CH2-; B is alkylene which is bonded with an aromatic ring through O, S, SO, etc.; Q is C or N; R1 is H or residue of formula II; R2 is (hydroxy)alkyl, halogen, OH, lower acyl, nitro, etc.; (m) is 1 or 2; (n) is 1-3]. EXAMPLE:1-Isopropylamino- 3-[ 3-( 2-nitratoethoxy )phenoxy ]-2- propanol of formula III. USE:Antistenocardia, hypotensor, cerebral circulation improver, and antiarrythmia. PROCESS:The compound of formula I is prepared, e.g. by (1) converting the compound of formula IV (P is OH, acetyl, halogen, etc.) to the aminoalkanol derivative of formula V, and (2) nitrating the compound with fuming nitric acid, etc. pref. at -40 deg.C- room temperture for several minutes to 1hr. |
