| 摘要 |
NEW MATERIAL:The compound shown by the formula I [Y is 0, -(CH2)m-; m is 0 or 1; n is 1 or 2; R1-3 are H, lower alkyl, halogen, etc.; R4 is lower alkyl, a group shown by the formula II, etc.] and its acid addition salt. EXAMPLE:2-Methyl-2-azaerythrinan. USE:A drug. Having depressing action of central nervous system, especially strong pain-killing action. PROCESS:A compound shown by the formula III (R6 is alkyl) is condensed with a compound shown by the formula IV under heating, and subjected to ring closure under acidic conditions, to give a compound shown by the formula V. The lactam ring of the compound shown by the formula V is then reduced with lithium aluminum hydride, boran, etc., to give a compound shown by the formula I. |
