| 摘要 |
Napth[1,2-d]imidazoles and naphth[2,1-d]oxazoles of formula
<CHEM>
wherein R and R1 and hydrogen, halogen, alkyl or alkoxy, R2 stands for hydrogen or halogen and A represents one of the following moieties
<CHEM>
wherein R3 represents alkyl, cycloalkyl, or a -(CH2)nNR5R6 group in which n is 1,2, or 3, R5 stands for hydrogen or alkyl, R6 is alkyl or R5 and R6 taken together with the adjacent nitrogen atom may represent a 4 to 7 membered saturated hetero-ring which may contain a further hetero atom and optionally be substituted e.g. with phenyl and substituted phenyl, R4 stands for hydrogen, alkyl, cycloalkyl or a -(CH2)nNR5R6 group provided that one of R3 and R4 is a -(CH2)n-NR5R6 group, and R7 is -(CH2)n-NR5R6, and their pharmaceutically acceptable acid addition salts are made e.g. by contacting the corresponding naphth[1,2-d]imidazoles or naphth[2,1-d]oxazoles wherein one of R3 and R4 or R7 is a -(CH2)nX group where X stands for the residue of a reactive ester with the proper amine of formula HNR5R6 in the presence of an acid acceptor agent. The new compounds are useful as CNS depressant agents.
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