| 摘要 |
1488692 Pyrazolo[3,4b]quinolines BRISTOLMYERS CO 30 Sept 1974 [1 Oct 1973] 42353/74 Heading C2C A novel compound of Formula I or a pharmaceutically acceptable salt thereof, where E is hydrogen, halogen, lower alkoxy, lower alkylthio, thio, trifluoromethyl, lower dialkylaminoalkoxy, amino, lower alkylamino or lower dialkylamino, where F is hydrogen, lower alkyl, lower alkoxyl, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower dialkylaminoalkoxy, amino, lower alkylamino or lower dialkylamino, where G is hydrogen, halogen, lower alkyl, lower alkoxyl, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower dialkylaminoalkoxy, amino, lower alkylamino or lower dialkyl amino. where J is hydrogen, halogen, lower alkoxy, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower dialkylaminoalkoxy, amino, lower alkylamino or lower dialkylamino, where n is an integer from 2 to 12 inclusive, and Y is amino, lower alkylamino, lower dialkylamino, or a heteroamino group wherein the heteroamino group is a 5 or 6 membered saturated substituted or unsubstituted ring; and where when n is 3 and Y is lower dialkylamino at least one of E, F, G and J is other than hydrogen; are prepared by reaction of a compound of Formula I above wherein Y is halogen with an appropriate amine. Various intermediates are prepared according to the following reaction schemes Pharmaceutical compositions in conventional forms for oral or parenteral administration and having anti-viral activity comprise an above novel compound and a carrier or diluent. |
