发明名称 |
SETT ATT FRAMSTELLA NYA AUALOGER AV DEAMINO-VASOPRESSIN MED MODIFIERAD DISALFIDBRYGGA |
摘要 |
Stepwise synthesis in solution and cyclization by means of active esters or another method suitable for peptide bond formation were used to prepare analogues of deamino-vasopressin with the disulphide bridge altered to the thioether group. In sequence position 8 of the peptide chain the analogs differed by the nature of basic amino acid. Typical vasopressin-like activities, mainly antidiuretic, were very high in these analogs; of particular importance will be their haemodynamic activity. |
申请公布号 |
SE419753(B) |
申请公布日期 |
1981.08.24 |
申请号 |
SE19740011817 |
申请日期 |
1974.09.19 |
申请人 |
* CESKOLOVENSKA AKADEMIE VED |
发明人 |
Z * PROCHAZKA;T * BARTH;J H * CORT;K * JOST;F * SORM |
分类号 |
A61K38/00;A61K38/11;A61P5/00;C07K1/113;C07K5/103;C07K7/16;C07K14/575;(IPC1-7):07C103/52 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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