SOMATOSTATIN ANALOGS HAVING A SUBSTITUTED TRYPTOPHYL RESIDUE IN POSITION EIGHT

摘要

AHP-7308 SOMATOSTATIN ANALOGS HAVING A SUBSTITUTED TRYPTOPHYL RESIDUE IN POSITION EIGHT Tetradecapeptides of the formula in which A represents L, D or DL 5- or 6- fluoro, bromo-,chloro- or iodotryptophyl, or a therapeutically acceptable acid addition salt thereof, their preparation and intermediates for their preparation are disclosed. The tetradecapeptides are useful for inhibiting the release of growth hormone. Compositions and methods for their use also are disclosed.