| 摘要 |
This invention relates to new cephem compounds. More particularly, it relates to new 7-substituted-3-cephem-4-carboxylic acid, its pharmaceutically acceptable salt and pharmaceutically acceptable bioprecursor thereof, which have antimicrobial activities, and processes for preparation thereof, to intermediate for preparing the same and processes for preparation thereof, and to pharmaceutical composition comprising the same and methods of using the same prophylactically and therapeutically for treatment of infectious diseases in human beings and animals. The cephem compounds of this invention include the compound represented by the formula (I): <IMAGE> (I) wherein R1 is amino or protected amino, R2 is lower alkyl substituted with a substituent selected from the groups consisting of cyano, carbamoyl, hydroxy, protected hydroxy, amino, protected amino, lower alkoxy, lower alkylthio, lower alkenylthio, aryl which may have one or more suitable substituent(s), and heterocyclic group which may have one or more suitable substituent(s), R3 is carboxy or protected carboxy, and R4 is hydrogen or halogen, and their pharmaceutically acceptable salts or pharmaceutically acceptable bioprecursors thereof.
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