| 摘要 |
New and pharmacologically useful tetracyclic compounds are disclosed of the formula (I): <IMAGE> (I) and pharmaceutically acceptable non-toxic salts therefor, wherein: (a) R is hydrogen, alkyl of one to six carbons, aralkyl of seven to ten carbons, or an acyl group of one to six carbons; (b) R1, R2, R3 and R4 each represent hydrogen, hydroxy, halogen, alkyl of one to six carbons, alkoxy of one to six carbons, alkythio of one to six carbons, or trifluoromethyl; and (c) R5 represents hydrogen or an alkyl group of one to six carbons; as well as compositions containing these active compounds and methods of using same. The compounds of the instant invention have a remarkable pharmacological profile-one which clearly indicates the presence of anxiolytic properties with little or no sedative activity. The compounds according to the invention thus possess relatively specific anti-anxiety properties.
|
