| 摘要 |
The title compds. (I; R = C1-4 alkyl or C7-9 phenalkyl; R1 = H, C1-3 alkoxy or trifluoromethyl; R2 = H, C1-3 alkoxy, Br, F or Cl) useful as analgesics, anticonvulsants, and antidepressants were manufd. by oxidation of piperidine(II) with org. or inorg. peroxide in the presence of org. solvent. Thus, 1-nitroso-1,3-dihydro-3-phenylspiro(isobenzofuran-1,4'-piperidine) was mixed with glacial acetic acid and extracted to give 1'-amino-1,3-dihydro-3-phenylspiro(isobenzofuran-1,4'-piperidine), which was reacted with sodium cyanoborohydride to give 1'-(isopropylamino)1,3'-dihydro-3-phenylspiro(isobenzofuran-1,4'-piperidine.
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