摘要 |
<p>The novel derivatives of the nicotinic acid, having general formula:
<CHEM>
wherein R1 is H or methyl and R2 and R3, when separated, respectively represent OH and CH2OH, or are combined in a cyclic structure forming the group:
<CHEM>
show analgesic and anti-inflammatory activity associated with specific effects, or hypoglycemic and hypochlolesteremic activity. The subject derivatives are prepared by reacting (3-4) isopropyliden pyridoxine with the chloride of the nicotinic acid. </p> |