发明名称 Hydroxyalkyl and oxoalkyl substituted phenols as analgesics and sedatives
摘要 Compounds useful for pharmacological and medicinal purposes having the formulae <IMAGE> I and <IMAGE> II wherein R is H, C1-C5 alkanoyl; R1 is H, benzyl, C1-C5 alkanoyl, P(O)(OH)2, -CO(CH2)2COOH or a basic acyl group; each of R2 and R4 is H, C1-C6 alkyl, phenyl, pyridyl or (CH2)yC6H5; y is 1-4; R3 is H or CH3; Z is C1-C13 alkylene or -(alk1)m-O-(alk2)n-; each of (alk1) and (alk2) is C1-C13 alkylene with the proviso that the summation of carbon atoms in (alk1) plus (alk2) is not greater than 13; each of m and n is 0 or 1; and W is H, pyridyl, phenyl, fluorophenyl or chlorophenyl; intermediates therefor and methods for their preparation and use.
申请公布号 US4283569(A) 申请公布日期 1981.08.11
申请号 US19770832868 申请日期 1977.09.13
申请人 PFIZER INC. 发明人 ALTHUIS, THOMAS H.;HARBERT, CHARLES A.;JOHNSON, MICHAEL R.;MELVIN, JR., LAWRENCE S.
分类号 A61K31/11;A61K31/05;A61K31/075;A61K31/12;A61K31/325;A61K31/35;A61K31/40;A61K31/44;A61K31/4409;A61K31/4418;A61K31/445;A61K31/535;A61P7/10;A61P25/00;A61P25/04;A61P25/20;C07C27/00;C07C29/143;C07C37/00;C07C37/055;C07C39/11;C07C39/12;C07C39/15;C07C39/367;C07C41/00;C07C41/26;C07C43/178;C07C43/23;C07C45/00;C07C45/44;C07C45/67;C07C47/27;C07C47/277;C07C49/20;C07C49/245;C07C49/255;C07C49/76;C07C67/00;C07C69/007;C07C69/017;C07C69/157;C07C69/353;C07C229/06;C07D213/30;C07D295/15;C07F9/09;C07F9/12;C07F9/141;(IPC1-7):C07C39/06;C07C39/10 主分类号 A61K31/11
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