发明名称 |
PROCESS FOR PREPARING PYRIDYL COMPOUNDS |
摘要 |
<p>2-Aminopyrimidones which are histamine H2- antagonists having the structure in which Het2 is an optionally substituted 4-imidazolyl, 2-pyridyl or a 2-thiazolyl group; Y is sulphur or methylene; Z is hydrogen or lower alkyl; A is C1-C5 alkylene; R is lower alkyl or lower alkoxy; and R1 is hydrogen, lower alkyl or lower alkoxy, are prepared by a process in which an amine Het2-CH2Y(CH2)2NH2 is reacted with a compound of structure in which Q is nitroamino, lower alkylthio, benzylthio, chlorine, bromine or other group which can be displaced with a primary amine.</p> |
申请公布号 |
CA1106375(A) |
申请公布日期 |
1981.08.04 |
申请号 |
CA19790325180 |
申请日期 |
1979.04.09 |
申请人 |
SMITH KLINE & FRENCH LABORATORIES LIMITED |
发明人 |
BROWN, THOMAS H.;DURANT, GRAHAM J.;GANELLIN, CHARON R. |
分类号 |
C07D401/14;(IPC1-7):07D401/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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