| 摘要 |
The azetidine and aziridine derivatives of general formula: <IMAGE> and their non-toxic addition salts, in which R represents n-propyl, isopropyl, isobutyl or allyl and n = 0 or 1, are obtained by cyclising an alcohol of general formula: <IMAGE> by means of chlorosulphonic acid, triphenylphosphine dibromide or phosphorus pentoxide and by then reacting the base obtained with an acid to produce a non-toxic addition salt. Compound II can be obtained either by reduction of a corresponding ester or, if n = 0, by reaction of ethylene oxide with the corresponding amine. The azetidine and aziridine derivatives in question are useful in human or veterinary medicine as agents against Parkinson's disease or correctors of extrapyramidal disorders due to neuroleptics.
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