| 摘要 |
Novel cephalosporins of the formula <IMAGE> in which R1 represents hydrogen, alkyl or acyl and R2 represents hydrogen, alkyl or aryl and which can be present with respect to the centre of chirality C* in the two possible configurations R and S and as mixtures of the diastereomers resulting therefrom, and their non-toxic, pharmaceutically tolerable salts are prepared. These compounds are obtained by reacting an appropriate cephalosporin, which has an acetoxymethyl group in the 3-position, with a 5-mercapto-1,2,4-thiadiazole substituted in the 3-position by R1 in the presence of a base. Resulting compounds can be converted into the free acid and pharmaceutically tolerable salts. The novel cephalosporins are used as medicaments, in particular as antibacterial agents in infectious diseases. |
