DIGOXIN DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

The present invention provides 12-dehydrodigoxin oximes of the general formula: wherein R1 and R2, which can be the same or different, are hydrogen atoms, lower acyl radicals or lower alkyl radicals or R1 and R2 together can represent an alkylidene radical containing 2 to 6 carbon atoms and R3 is a hydrogen atom or a lower alkyl or aralkyl radical. The present invention also provides a process for the preparation of these oximes and pharmaceutical compositions containing them and is also concerned with the use of these oximes for the preparation of pharmaceuticals for the treatment of cardiac insufficiency.