发明名称 |
Lower-alkyl 4,6,7,8,8a-9-hexahydro-6,9-ethanothieno[3,2-f]indolizine-10-carboxylate |
摘要 |
Compounds of tropane (8-azabicyclo[3.2.1]octane) series having an aromatic substituent in the 2-position and a carboalkoxy group in the 3-position are prepared by reacting a tropane-3-carboxylate having a double bond in the 2,3-position with an aryl Grignard reagent. Transformations of the substituent on nitrogen are subsequently effected. Compounds where the 3-carboalkoxy group is in the exo configuration possess hypoglycemic activity, and those where the 3-carboalkoxy group is in the endo configuration possess narcotic antagonist activity.
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申请公布号 |
US4281130(A) |
申请公布日期 |
1981.07.28 |
申请号 |
US19790088536 |
申请日期 |
1979.10.26 |
申请人 |
STERLING DRUG INC. |
发明人 |
CLARKE, ROBERT L.;DAUM, SOL J. |
分类号 |
C07D451/02;C07D495/22;(IPC1-7):C07D513/22;C07D513/18 |
主分类号 |
C07D451/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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