| 摘要 |
PURPOSE:To obtain the titled compound which is a raw material for an indole derivative and an alkaloid in high yield, simply by reacting a phenylhydrazing compound with a 4-1minobutanal dialkyl acetal compound under weakly acidic conditions through condensation and cyclization. CONSTITUTION:A phenylhydrazine compound of formula I (R is H, alkyl, aryl, aralkyl, nitro or halogen; R<1> is R<2> as described below, etc.) is reacted with a 4- aminobutanal dialkyl acetal compound having at least one group of formula II (R<2> is H, alkyl, aryl, aralkyl or hydroxyalkyl; R<3> is R<2>, etc.) in water or a hydrophilic solvent or a mixed solvent of two or more thereof in a pH range of 0.8-4.0 to give the aimed substance of formula III, e.g. N(beta)-acetyltryptamine. EFFECT:The aimed substance having various substitutents can be obtained without decomposition of the substitutents. USE:The comound mentioned above has a pharmacological action per se. |
