| 摘要 |
4-Dioxy-thiazolo-[5,4-c -rifamycin SV derivs. (I; R = H, C1-10 alkyl; R1 = H, acetyl) having bactericidal activity, were prepd. by the condensation of compds. II 1 mol and thioaminoic acid(III) 1-2 mol in C1-4 lower alkanol. Thus, 2.8 g triethylamine and 1.5 g α-amino-thiobutyric acid was added in 7 g rifamycin-dissolved 1L EtOH and maintained 3 hrs at 36oC, which was dried and recrystallized with ethylacetate and hexane to give 4-dioxy-2'-ethyl-thiazolo [5,4-c rifamycin SV.
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