| 摘要 |
PURPOSE:To obtain DL-serine useful as a raw material for an amino acid transfusion antibiotic, etc. in a short step and in high yield, by adsorbing aziridine-2- carboxylic acid which is easily prepared on a strongly acidic cation exchange resin, and heating the adsorbed carboxylic acid. CONSTITUTION:An aqueous solution of aziridine-2-carboxylic acid is passed through a strongly acidic cation exchange resin, preferably the H-type, and pure water is passed through the resin to adsorb the aziridine-2-carboxylic acid. The adsorbed aziridine-2-carboxylic acid is then heated at 40-120 deg.C, preferably 50- 100 deg.C, for 2-50hr to give DL-serine. The serine is eluted from the ion exchange resin with aqueous ammonia, etc., and the eluate is concentrated to dryness and isolated. |
