| 摘要 |
<p>Process for the manufacture of new azatetracyclic compounds of the formula (I) wherein R1 represents hydrogen, lower alkyl, cycloalkyl-lower alkyl of not more than 10 carbon atoms, lower alkenyl, lower alkynyl, (di-lower alkylamino)-lower alkyl, hydroxy lower alkyl, alkoxy lower alkyl, alkanoyloxy lower alkyl, lower alkylthio-lower alkyl, phenyl-lower alkyl, or phenyl-lower alkyl substituted by halogen with an atomic number up to 35, lower alkyl, lower alkoxy, methylenedioxy, or trifluoromethyl, the ring A is unsubstituted or substituted by halogen with an atomic number up to 35, lower alkyl, hydroxyl, lower alkoxy, alkanoyloxy, lower alkylthio, trifluoromethyl or cyano, Y represents a direct bond, Z represents vinylene and X represents O, S, methylene, a direct bond or a divalent radical of the partial formula (Ia) in which R3 represents hydrogen or lower alkyl, or Y represents a direct bond, Z represents S and X represents a direct bond or S, and acid addition salts thereof. The novel compounds possess valuable pharmaceutical properties and can be used as tranquillizing, antipsychotic and excitationinhibiting compounds for the treatment of states of agitation.</p> |
