| 摘要 |
NEW MATERIAL:A compound of formula I [R is secondary amino; R<1> and R<2> are H or alkyl; R<3> is alkyl or cycloalkyl which may have one substituent (CN, phenyl, etc.), alkenyl which may have one substituent (phenyl, alkoxyl, etc.); aryl which may have one or two substituents (OH, halogen, etc.) or heterocyclic group which may have one substituent (=O, halogen, etc.); X is O or S] and a pharmaceutically acceptable acid addition salt thereof. EXAMPLE:N-{ 2-[[ (5-Dimethylaminomethyl-2-furyl)methyl ]thio]-ethyl }-2-thiophenecarbonamide. USE:A histamine H2 inhibitor useful as a remedy for diseases which are improved by the inhibition of the histamine H2 action such as peptic ulcer. PROCESS:A compound of formula II is reacted with an acylating agent constituted of R<3>CO- by the conventional method to give the compound of formula I. |
