摘要 |
A process for brominating or chlorinating 2-fluoroaniline in a solvent, in which the solvent comprises dimethylformamide or dimethylacetamide. For example, 4-bromo-2- fluoroaniline can be prepared by reacting 2-fluoroaniline with bromantin in the presence of dimethylformamide. The product can be used as an intermediate in the preparation of flurbiprofen.
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