| 摘要 |
PURPOSE:An antitumorigenic agent that contains a 5-fluoropyrimidine, thus showing increased antitumorigenic activity and reduced toxicity. CONSTITUTION:The antitumorigenic agent contains a 5-fluoropyrimidine selected from 5'-deoxy-5-fluorouridine or 5'-deoxy-5-fluorocytidine and a uracyl selected from uracil, thymine and thymidine, preferably at a ratio of 1mol of the former to 0.5mol or more of the latter. A uracil itself does not show antitumorigenic effect, however, the addition of this compound remarkably increases the antitumorigenic effect of 5-fluoropyrimidine (6 times in an example). Further, no acute toxicity is observed even when the maximum dose that is technically possible in an experiment is administered. |
