| 摘要 |
Thiophene carboxamides are described of general formula I <IMAGE> in which the amide function is in the 2- or 3-position on the thiophene ring, R1 to R5 inclusive are hydrogen atoms or lower alkyl groups, X is -CH2-, -O- or -NR6- where R6 is hydrogen or a lower alkyl group, n is a number from 0 to 3 and Ar is an optionally substituted phenyl group and their physiologically acceptable salts. The compounds have been found to lower blood pressure in animals and to exhibit a blocking action at beta -adrenoreceptors and their use is indicated for the treatment of cardiovascular disorders such as hypertension and angina. Some of the compounds also exhibit a blocking action on alpha -adrenoreceptors and their use is indicated for the treatment of hypertention. |
