(ALPHA)-(3-AZETIDINYL)-(ALPHA)-PHENYL ACETONITRILE AND ACETAMIDES

摘要

.alpha.-(1-R-3-Azetidinyl)-.alpha.-phenyl-.alpha.-substituted-acetamides and acetonitriles represented by the following formula: wherein R represents hydrogen, C1-C8 alkyl, C3-C9 cycloalkyl or phenyl C1 C8 alkyl, R1 represents phenyl or 2-pyridyl, and Y is carbamoyl or cyano having antiarrhythmic activity are disclosed. Pharmaceutically acceptable acid addition salts of the free bases and quaternary salts are included as part of the invention.