| 摘要 |
Somatostatin analogs(I) were prepd. by oxidn. of, III. Thus, Me3CO2C-Ala-Gly-Cys-(CH2C6H4OMe-P)-Lys(Ecl-2)-Asn-Phe-Trp-Lys(Ecl-2)-Thr(CH2Ph)-D-Phe-Thr(CH2Ph)-Ser(CH2PH)-Cys(CH2 C6H4O-Me-P)-OCH2Q(ZCl-2=CO2CH2C6H4Cl-2) was prepd. by the solid-phase method and treated with HF to give the corresponding unprotected linear tetradecapeptide which was oxidized to give I(X = D-Phe) (II). II at 50 μg inhibited the increase in serum GH of rats by 70 %.
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