2-Oxo-4-imidazoline-1-alkanoic acid derivs. - with antithrombotic, anti-arteriosclerotic and antiinflammatory activity, prepd. e.g. by reaction of benzoin cpd. with ureido-alkanoic acid

摘要

New omega-(2-oxo-4-imidazolin-1-yl) alkanoic acid derivs. are cpd. of formula (I). In (I) n is 1-10; R1 is phenyl or substd. phenyl; and R2 is H, an alkali ion, an opt. branched satd. 1-6C hydrocarbon chain or aralkyl. Specific (I) include (4,5-diphenyl-2-oxo-4-imidazolin-1-yl) acetic acid; 8-(4,5-diphenyl-2-oxo-4-imidazolin-1-yl caprylic acid; and 8-/4,5-bis(2-fluorophenyl)-2-oxo 4-imidazolin 1-yl/-caprylic acid. Prepn. of (I) (R2 is H) comprises e.g. reacting R1CH(R1CO)OH with H2NCONH(CH2)nCOOR2 in acidic medium.(I) have antithrombotic, antiarteriosclerotic and antiinflammatory activity, with good gastric tolerance and low toxicity.