| 摘要 |
PURPOSE:To prepare the titled compound extremely useful for the production of pharmaceuticals, in high yield, with simple operation, in one step, i.e. the direct decarboxylation reaction, by heat decomposing a farnesylmalonic acid diester in the presence of a specific catalyst. CONSTITUTION:A farnesylmalonic acid diester of formula III (R is group of formula IV; R1 and R2 are alkyl or alkenyl) is subjected to thermal decomposition in the presence of an amide compound of formula I [when X and Y do not form a ring together with the residue of formula II, then X is H, alkyl, or mono or dialkyl-substituted amino; Y is alkyl; and Z is H or alkyl; and when X and Y form a ring, -X-Y- is -(CH2)n-; n is >=1], water, and an alkali metal halide or cyanide, to obtain the objective compound. The reaction is carried out usually at 100-190 deg.C, pref. 150-180 deg.C, for 5-20hr. |
