摘要 |
The invention comprises phenol substitutes in either the 2- or the 4-position by a pinan-1-yl radical and in at least one other position by a methyl radical, substituents other than pinan-1-yl and methyl being absent; the compounds are made by reacting camphene with an appropriate methyl-substituted phenol, in presence of a Friedel-Crafts catalyst, e.g. SnCl4. Exemplified products have the following structures <FORM:1062252/C2/1>ALSO:Pharmaceutical compositions for treating infections caused by pyogenic microorganisms comprise, besides a carrier, a phenol substituted in either the 2- or the 4-position by a pinan-1-yl radical and in at least one other position by a methyl radical, substituents other than pinan-1-yl and methyl being absent; the compounds may be used in the form of skin ointments, percutaneous ointments, suppositories, capsules, alcoholic solutions, suspensions for atomisation, ear drops, tablets and suspensions for intramuscular or subcutoneous injections. The compounds may be associated with an antispasmodic a B-group vitamin or a lactic ferment. Exemplified substituted phenols have the following structures: <FORM:1062252/A5-A6/1> |