Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof.

摘要

Compounds of the general formula: …… wherein R is hydrogen, C1-C4 alkyl, or halogen;… Y is (CH2)n, where n is 1 to 4, benzyl or CH2-(Het)- where Het represents a 5 or 6 membered aromatic heterocyclic ring linked to Z by a ring carbon atom;… Z is CO2R<1>, CONHR<2>, CON(R<3>)2, COCO2R<1>, COCONHR<2>, COCON(R<3>)2, CN or 5-tetrazolyl, or, when Y is -CH2-(Het),C1-C4 alkyl where:… R<1> is H or C1-C4 alkyl,… R<2> is H, C1-C4 alkyl, C2-C4 alkanoyl, C1-C4 alkylsulphonyl, CN, benzoyl or benzenesulphonyl, the phenyl ring in said benzoyl or benzenesulphonyl groups being optionally subsituted,… each R<3> is C1-C4 alkyl or two groups R<3> together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or morpholino group;… the group -O-Y-Z being attached to the 3 or 5 position of the pyridine ring,… and the pharmaceutically acceptable salts thereof and bio-precursors therefor are able to selectively inhibit the action of the thromboxane synethetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclooxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis, migraine and the vascular complications of diabetes.