Preparation of cyanoacetamide and 2,2-dibromo-3-nitrilopropionamide compositions.

摘要

An alkyl alpha -cyanoacetate is reacted with ammonia in a glycol solvent medium to form cyanoacetamide. Advantageously and without requirement of separation of the formed cyanoacetamide in glycol solvent (even though the next step and entire procedure can optionally commence with pre-formed cyanoacetamide), 2,2-dibromo-3-nitrilopropionamide is formed in situ by treating the cyanoacetamide in glycol with an appropriate mixture of bromine and an alkali metal bromate at about 10 DEG C-40 DEG C. Excellent and stable antimicrobial compositions may then be prepared, as part of an overall integrated process by incorporating in the resultant 2,2-dibromo-3-nitrilopropionamide-containing reaction mass an appropriate quantity of paraformaldehyde or equivalent satisfactory stabilizer at a suitably adjusted pH level.